Microdensitometric study of maturation and fragility of the bone in male patients with cerebral palsy. The effect of long term administration of 1.ALPHA.-hydroxy vitamin D3 and the value of osteocalcin as a marker of bony growth.:The Effect of Long Term A

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• 1) We studied bony maturation and fragility in 48 male patients (4-28 years old) with cerebral palsy. They were divided into three groups group A (drug free, mild motor handicapped), 10 cases, group B. (anticonvulsants administrated, mild motor handicappe'd), 20 cases, group C (anticonvulsants administrated, severe motor handicapped) 18 cases. The indicator of bone mineral content (ΣGS/D) and metacarpal index (MCI) were analyzed by microdensitometric method.<BR>A positive correlation between age and ΣGS/D was detected in all groups but a positive correlation between age and MCI was found only in the group B. There was little difference in ΣGS/D and MCI between group A and group B, but those of group C were significantly decreased. These results suggest that increase Df bone mineral is related with aging but metacarpal growth is variable, and a lack of daily activity has greater adverse effect on bony metabolism than administration of anticonvulsants.<BR>2) The alterative rates of ΣGS/D (ΔΣGS/D/ΣGS/D/year) and MCI (ΔMCI/MCI/year) after 1α-hydroxy vitamin D<SUB>3</SUB> (D<SUB>3</SUB>) treatment for 3 years or more were examined in 17 patients with bony atrophy, as compared with normal controls. The alterative rates of ΣGS/D and MCI were elevated in younger patients with D<SUB>3</SUB> treatment but those were decreased in adult patients. Treatment with D<SUB>3</SUB> remarkably increased bony growth in children.<BR>3) In 37 patients, osteocalcin (OC) was measured by radioimmunoassay. OC was elevated in younger patients who were treated with D<SUB>3</SUB>. A positive correlation between OC and alterative rate of ΣGS/D was found in patients with D<SUB>3</SUB> treatment (r=0.728, p<0.02) and patients without treatment (r=0.758, p<0.02). OC is considered to be a very valuable marker to evaluate bony growth.

• 一般社団法人 日本小児神経学会の論文

一般社団法人 日本小児神経学会 | 論文

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