Pituitary reserve of growth hormone in adolescent patients with cerebral palsy and mental retardation.

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The pituitary reserve of growth hormone (GH) was studied in 11 severely handicapped boys (14-18 years old) with mental retardation and cerebral palsy (CP); athetotic type 4 cases, and spastic type 7 cases. Serum GH was determined before and after intravenous injection of 1 ng/kg growth hormone releasing factor (GRF) or oral administration of 0.1 mg/m<SUP>2</SUP> clonidine. The athetotic type patients showed low somatomedin C (Sm C) concentrations (0.31±0.11 U/ml), poor responses to clonidine, and good responses to GRF. The spastic type patients showed subnormal responses to GRF although their Sm C was normal (0.91±0.43 U/ml). Clinically, the stature was small, and the puberty was delayed in the former. The levels of plasma testosterone were significantly lower than those in the latter. It is concluded that athetotic type CP was associated with hypothalamic GRF deficiency and spastic type CP was associated with reduced pituitary reserve of GH.
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