Possible adverse effects of phenytoin given transplacentally on the fetal growth. I. Transplacental transmission of phenytoin.:I. Transplacental Transmission of Phenytoin

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This study was undertaken to examine the transplacental transmission of phenytoin (PHT) and its possible adverse effects on the fetal growth. The animals used in this experiment were 8-week-old female mice of the ICR-JCL strain. When 50mg/kg of body weight of PHT was administered orally to mothers with chow, maternal serum levels of PHT were the lowest at noon and highest at midnight. The concentration of PHT in serum showed a close correlation with each dose increment, when blood was drown at a certain time. Serum levels of PHT in the fetus were about 80% of those in maternal serum on day 18 of gestation. The differences in serum levels of PHT between the fetuses and their mothers were attributed to the differences in levels of albumin-bound PHT, and the level of albumin- free PHT in the fetuses were almost same as that in their mothers.
一般社団法人日本小児神経学会の論文