Regional cerebral blood flow in various pediatric neurological patients using 123I-IMP SPECT.
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The recent developmento f a new radiopharmaceutical <SUP>123</SUP>I-isopropyl-iodoamphetamine (IMP), which is taken up by the brain from the blood flow, has offered a possibility of constructing scintigraphy maps of regional cerebral blood flow (rCBF) using single photon emission CT. We used this method in various pediatricn eurologicald iseases.<BR>Six patients with cerebro-vasculard isorders (moya-moyad isease2, infarction3 and HHE syndrome1), 6 patients with infectiousd iseaseso f CNS (acute encephalitis4, septic meningitis1 and SSPE 1) and a miscellaneous group of six patients were studied. The rCBF abnormalitiesi n cerebro-vasculard iseases were more extensive and frequent than x-ray CT abnormalities.R epeateds tudieso f IMP-SPECTr evealedu sefulness for the understandingo f changeableh emodynamicp athophysiologya nd for the judgment of theraptic effectivenessa nd prognosis.T he rCBF decrease in infectiousd iseasest ended to be more diffuse and slight than that in cerebro-vasculard iseases. In almost all patients, t he area of rCBF decrease coincidedw ith the area of EEG slowing evaluated by EEG topographic analysis.<BR>Brain imaging using <SUP>123</SUP>I-IMPS PECT may reveal functional abnormalitiesa s well as organic lesions.<SUP>123</SUP>I-IMPS PECT has introduceda new era for the useful applicationo f nuclearm edicinet o the investigation of pediatricn eurologicadl iseases.
- 一般社団法人 日本小児神経学会の論文
一般社団法人 日本小児神経学会 | 論文
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