Brain development in the symptomatic obesity model mouse with brain dysfunction. II. Dendritic development of neurons in the cerebral cortex.:II. Dendritic Development of Neurons in the Cerebral Cortex

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Mice injected with monosodium L-glutamate (MSG) in the neonatal period become obese in adulthood and have a short body length, hypogonadism and microcephalus. These MSG- treated mice may be a model of symptomatic obesity with brain damage such as the case of Laurence-Moon-Biedl syndrome. This study was undertaken to investigate the dendritic development of pyramidal cells in the cerebral cortex of MSGtreated mice.<BR>Male Jcl; ICR strain mice were subcutaneously injected with MSG daily for the first five days of life. MSG-treated mice, as well as control mice, were sacrificed at 30, 60, 90 and 120 days, and their brains were then processed by the Golgi-Cox technique. In coronal sections, dendritic development of pyramidal cells in layer 5 in the parietal region (area 1) was assessed quantitatively according to Eayrs' method. The dendrites of MSG-treated mice were shorter than those of controls, and the density of dendrites in MSG-treated mice was less than that in controls in the distal zone from the perikarya. Although the dendrites of MSG-treated mice showed the "catch up" phenomenon especially in the proximal zone, the recovery was not enough as a whole.<BR>These results suggest that mentally retarded patients with symptomatic obesity may have similar developmental aberration of dendrites in their brains.
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