A case of neonatal herpes simplex encephalitis.

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A one-month-old girl was admitted with sucking difficulty and hypothermia. She was spontaneously born at 36 weeks of gestation and had fever on 15 and 16 days after birth. Muscle hypotonus, hyperactive deep tendon reflexes and decrease of primitive reflexes were noticed on admission. Hepatosplenomegaly and dermal vesicles were not found. Convulsions continued for about one month after the admission.<BR>Peculiar calcifications in white matter and periventricular areas were always detected by serial findings of brain CT scan. Multicystic encephalomalacia was shown by brain echogram. EEG disclosed flat rhythms.<BR>Antibodies to herpes simplex virus, probably type 2, and echovirus, type 22, were presented in high titers in bloods and CSFs. Echovirus was cultured from throat swab. Herpes simplex virus was not cultured from either blood of CSF.<BR>HSV encephalitis without ecovirus encephalitis was considered from the results of virus antibody titers in bloods and CSFs.<BR>Microcephalus and cerebral palsy developed subsequently. Anti-viral drugs were not used.
一般社団法人日本小児神経学会の論文