:2. A Study of Serum Cortisol Level and Clinical Effectiveness in Infantile Spasms Using Lower Doses of ACTH-Z Treatment

概要

論文の詳細を見る
Ten patients with infantile spasms were investigated by monitoring serial serum cortisol levels during ACTH-Z treatment. Lower doses of ACTH-Z were used for the purpose of reducing a serious side effects yet maintaining favorable clinical effectiveness. Patients were divided into three groups (group I: 0.025 mg/kg, group II: 0.0125 mg/kg, group III: 0.0125→0.025 mg/kg) according to the doses of ACTH-Z given. Fourteen days of consecutive ACTH-Z administration revealed a significant increase of serum cortisol level in all groups investigated. However, among the three groups, group I demonstrated a significantly higher level of serum cortisol. All the cases in group I showed an excellent clinical response to ACTH-Z therapy. On the other hand 60% of cases in both groups II and III whose treatment was initiated by 0.0125 mg/kg of ACTH-Z showed a poor clinical response. This observation suggests that 0.025 mg/kg of ACTH-Z is effective enough to control infantile spasms favorably with less side effects.
一般社団法人日本小児神経学会の論文