Molecular Cloning and Genomic Analysis of Mouse Glucuronyltransferase Involved in Biosynthesis of the HNK-1 Epitope.
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概要
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eDNA and genomic clones encoding the mouse glucuronyltransferase (GlcAT-P) involved in biosynthesis of the HNK-1 carbohydrate epitope were isolated and the structural organization of the gene was determined. The predicted amino acid sequence of mouse GIcAT-P is 96.2 and 98.2% identical to those of the rat and human enzymes, respectively. Alternatively spliced isoforms of mouse GIcAT-P are present in the brain and encode two proteins that are identical throughout their length except for an additional 13 amino acids in the N-terminal cytoplasmic domain of the major form. The coding region of GlcAT-P is composed of 5 exons spanning approximately 6 kb, and the GIcAT-P gene was mapped to the A 4 region of mouse chromosome 9. Upstream of the transcriptional start site, no typical TATA or CCAAT box was found, but binding sites for several known transcription factors including Spl and Krox-20 were identified. Transient transfection of luciferase reporter constructs demonstrated that a 207 bp fragment of the 5'-upstream region acts as a strong promoter in PC-12 cells, which express the HNK-1 epitope, but not in COS-1 cells. Thus, this minimal promoter region of GlcAT-P is suggested to be associated with the regulation of HNK-1 expression.
- 社団法人 日本生化学会の論文
著者
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Inazawa Johji
Department Of Hygiene Kyoto Prefectural University Of Medicine
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Saito-ohara Fumiko
Department Of Cytogenetics Medical Research Institute Tokyo Medical And Dental University
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Yamamoto Shoji
Department Of Biological Chemistry And Crest (core Research For Educational Science And Technology)
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OKA Shogo
Department of Biological Chemistry and CREST (Core Research for Educational Science and Technology)
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Kawasaki Toshisuke
Department Of Biochemistry Kyoto University
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Kawasaki Toshisuke
Department of Biological Chemistry and CREST (Core Research for Educational Science and Technology) Project, Japan Science and Technology Corporation, Graduate School of Pharmaceutical Sciences, Kyoto
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