CARCINOEMBRYONIC ANTIGEN (CEA) FAMILY GENES ARE LOCATED ON HUMAN CHROMOSOME 19 AT BAND q13.2 (<Symposium>In situ Hybridization III. : Application for Medical Investigation)

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概要

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• The chromosomal localization of four newly isolated carcinoembryonic antigen (CEA) family genes was determined by the combined use of the Southern blot hybridization of hybrid cells and cell sorted chromosome DNAs, and in situ hybridization. CEA, one of the most widely used human tumor markers, is a member of a gene family comprising over 10 closely-related genes and constitutes a subfamily within the immunoglobulin (Ig) superfamily. Recent success of analysis at molecular level revealed that nonspecific cross-reacting antigen (NCA) and pregnancy specific β1-glycoprotein (PSβG) also belong to the CEA gene family. We mapped CEA, NCA, and two different PSβG genes to chromosome 19 at band q13.2. These results suggest that almost all CEA family genes are located within a limited region on chromosome 19 in a manner similar to the major histocompatibility (MHC) genes, which also belong to the Ig superfamily, and which are localized within bands p21.1-p21.3 on chromosome 6.

• 日本組織細胞化学会の論文

著者

• ABE Tatsuo

  Department of Hygiene, Kyoto Prefectural University of Medicine

• INAZAWA Johji

  Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, T

• Abe Tatsuo

  Department Of Hygiene Kyoto Prefectural University Of Medicine

• Inazawa J

  Department Of Molecular Cytogenetics Medical Research Institute Tokyo Medical And Dental University

• Inazawa Johge

  Department Of Hygiene Kyoto Prefectural University Of Medicine

• Inazawa Johji

  Department Of Hygiene Kyoto Prefectural University Of Medicine

• Inazawa Johji

  Department Of Molecular Cytogenetics Medical Research Institute And Graduate School Of Biomedical Sc

• Abe Tatsuo

  Department Of Hygiene Kyoto Prefictural University Of Medicine

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