Integrin-Associated Protein (IAP, Also Termed CD47) Is Involved in Stroma-Supported Erythropoiesis.

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概要

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• Erythropoiesis is regulated by the hematopoietic microenvironment of the spleen, fetal liver, and bone marrow in mice. We previously showed that established stromal cells from these organs selectively support erythropoiesis in vitro. To identify the cell surface molecule (s) on the stromal cells involved in erythropoiesis, we raised monoclonal antibodies (MAbs) to MSS 62 stromal cells derived from newborn spleen and obtained MAb 100.1, which partially inhibited the stroma-supported erythropoiesis in vitro. Using an expression cDNA library of MSS 62 cells, we cloned a gene encoding the protein recognized by MAb 100.1 and identified it as integrin-associated protein (IAP, also termed CD47), which may play a general role in integrin-mediated signal transduction. IAP/CD 47 is expressed in the stromal cells of spleen, fetal liver, and bone marrow, and in a variety of hematopoietic cells including erythroblasts. Thus, IAP may be partly involved in the erythropoietic supporting ability of the stromal cells.

• 社団法人 日本生化学会の論文

著者

• Yanai Nobuaki

  Department Of Biological Science Tohoku University

• Obinata Masuo

  Department Od Cell Biology The Research Institute For Tuberculosis And Cancer Tohoku University

• FURUSAWA Tadashi

  Department of Cell Biology, Institute of Development, Aging and Cancer, Tohoku University

• HARA Takahiko

  Laboratory of Cellular Biosynthesis, Institute of Molecular and Cellular Biosciences, The University

• Miyajima Atsushi

  Laboratory Of Cell Growth And Differentiation Institute Of Molecular And Cellular Biosciences Univer

• Furusawa Tadashi

  Department of Cell Biology, Institute of Development, Aging and Cancer Tohoku University

• MIYAJIMA Atsushi

  Laboratory of Cellular Biosynthesis, Institute of Molecular and Cellular Biosciences, The University of Tokyo

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