The 5'-Flanking Region of the Human Smooth Muscle Cell Calponin Gene Contains a cis-Acting Domain for Interaction with a Methylated DNA-Binding Transcription Repressor.
スポンサーリンク
概要
- 論文の詳細を見る
The human smooth muscle cell (SMC) calponin gene, which is composed of seven exons and six introns, spanning an approximately 11.2 kilobase (kb) genomic DNA, has been isolated and characterized by sequence analysis. As determined by primer extension mapping and rapid amplification of mRNA transcripts, a major transcription start site of the calponin gene is located at 101 base-pairs (bp) upstream of the ATG start codon. A striking feature of the 5'-flanking, 5'-untranslated, and amino-terminal protein coding regions is the presence of an Alu repetitive sequence and a stretch of DNA sequence identified using a methyl CpG-binding protein affinity column [Cross, S. H., Charlton, J. A., Nan, X., and Bird, A. P. (1994) Nature Genet. 6, 236-244]. The results of this study provide a new insight into the molecular mechanism underlying regulation of SMC-lineage specific gene expression.
- 社団法人 日本生化学会の論文
著者
-
Miwa Takeshi
Genome Information Research Center
-
Miki Akiko
Department Of Biological Science Faculty Of Science Yamaguchi University
-
OKADA Tsutomu
Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd.
-
Ohgami Kinya
Pharmaceutical Research Laboratory Kirin Brewery Co. Ltd.
-
Shibata Nobuhiko
Department Of Cardiology The Center For Adult Diseases
-
Tazunoki Tetsushi
Pharmaceutical Research Laboratory Kirin Brewery Co. Ltd.
-
Takahashi Katsuhito
Department Of Medicine Molecular Biology Unit Osaka Medical Center For Cancer And Cardiovascular Dis
関連論文
- Prognostic factors for progression of early- and late-stage calcific aortic valve disease in Japanese : The Japanese Aortic Stenosis Study (JASS) Retrospective Analysis
- PE-284 Angiotensin Converting Enzyme Inhibitor And Angiotensin II Type1 Receptor Antagonist Differently Modulate Extracellular Matrix Regulatory System in Diastolic Heart Failure(Heart Failure, Clinical 10 (M) : PE49)(Poster Session (English))
- PE-182 Angiotensin II type1 Receptor Blocker Suppresses ROS Generation and Inflammatory Changes and Prevents Overt Diastolic Heart Failure in Hypertensive Hearts(Infection/Inflammation/Immunity 2 (H) : PE31)(Poster Session (English))
- A Case of Arrhythmogenic Right Ventricular Dysplasia With Left and Right Ventricular Hypofunction in an Elderly Subject : Long-Term Fellow-Up
- Angiotensin II type 1 receptor and endothelin type A receptor antagonists prevent ventricular fibrosis in hypertensive heart through different mechanisms
- Ca^-Sensitization of Contraction in the h1 Calponin-Deficient Smooth Muscle
- IS042 Mice lacking calponin display transdifferentiation of aortic smooth muscle into osteogenic-lineage cells that is associated with enhancement of bone morphogenetic protein responses
- Contractile Protein in the Case of Aortic Insufficiency Complicated with Aortic Arch Syndrome : PROCEEDINGS OF THE 25TH KINKI REGIONAL MEETING OF JAPANESE CIRCULATION SOCIETY
- Chronic Angiotensin Converting Enzyme Inhibition Prevented Development of Diastolic Heart Failure in Hypertensive Rats Through Modulation of Hypertrophic Signaling Pathway
- Activated renin angiotensin system deteriorates diastolic function through modulating Ca regulatory proteins and remodeling extracellular matrix
- Augmented collagen degradation rather than inhibition of synthesis accounts for beneficial effects of angiotensin-converting enzyme inhibition in diastolic heart failure
- Differential expression of serum response factor isoforms in the progression of heart failure due to hypertrophy
- Human Smooth Muscle α-Actin Promoter Drives Cre Recombinase Expression in the Cranial Suture in Addition to Smooth Muscle Cell
- Molecular Cloning and Characterization of Human Non-Smooth Muscle Calponin
- The 5'-Flanking Region of the Human Smooth Muscle Cell Calponin Gene Contains a cis-Acting Domain for Interaction with a Methylated DNA-Binding Transcription Repressor
- REEXAMINATION OF CHROMOSOMAL LOCI OF HUMAN MUSCLE ACTIN GENES BY FLUORESCENCE IN SITU HYBRIDIZATION
- RISK FACTORS IN ANGIOGRAPHICALLY DETERMINED CORONARY ARTERY DISESE (CAD) : Ischemic Heart disease : Ist Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
- IS079 Two comparable models of hypertensive heart failure : Diastolic failure vs systolic failure
- Structure and Expression of the Human SM22α Gene, Assignment of the Gene to Chromosome 11, and Repression of the Promoter Activity by Cytosine DNA Methylation
- The presence of h2-calponin in human keratinocyte
- Altered Mechanical Properties in Smooth Muscle of Mice with a Mutated Calponin Locus(Physiology)
- Activation of Xenopus Eggs by Cynops Sperm Extract is Dependent upon Both Extra-and Intra-Cellular Ca Activities
- ACID PROTEASE ACTIVITY IN EXPERIMENTAL MYOCARDIAL INFARCTION : IVth Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- AN APPROACH TO CARDIAC ARRYTHMIA AND INTERCELLULAR CONDUCTION DISTURBANCE FROM CULTURED HEART MUSCLE CELLS
- COLLAGEN METABOLISM ON MYOCARDIAL INFARCTION : PROCEEDINGS OF THE 38TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Identification of Myosin A, Actin and Native Tropomyosin Constituting of Arterial Contractile Protein (Myosin B) and Their Characteristics
- DYNAMIC CHANGES OF CARDIAC LYSOSOMAL ENZYMES IN EXPERIMENTAL MYOCARDIAL INFARCTION
- A Consideration of a Mechanism of Hypertension through Effects of Ions upon the Contractility Arterial Tissue and Its Contractile Protein
- THE CHARACTERISTICS OF CARDIAC AND ARTER.IAL CONTRACTILE PROTEIN : Proceedlngs of the 35th Annual Meetlng of the Japanese Circulation Society (part I)
- Effect of Catecholamines on Energy Metabolism of Myocardium
- The Effect of Sodium and Potassium Ions on the Contractility of a Contractile Protein Extracted from Arterial Wall
- OXIDATIVE PHOSPHORYLATION OF CARDIAC MITOCHONDRIA AND SUPERPRECIPITATION OF CARDIAC MYOSIN B
- THE EFFECTS OF CORONARY REPERFUSION ON EXPERIMENTAL MYOCARDIAL INFARCTION : Ischemic Heart Disease (VI) : FREE COMMUNICATIONS (VI) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- SCANNING ELECTRON MICROSCOPIC STUDIES ON THE FORMATION OF CARDIAC INTERCELLULAR CONNECTION IN CULTURE
- A CONSIDERATION ON THE FORMATION OF CARDIAC INTERCALETED DISK : APPLICATION OF THE SCANN-ELECTRON MICROSCOPE TO THE HEART CELL CULTURE : PROCEEDINGS OF THE 38TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Human Smooth Muscle α-Actin Promoter Drives Cre Recombinase Expression in the Cranial Suture in Addition to Smooth Muscle Cell
- EFFECTS OF HYALURONIDASE ADMINISTRATION ON ACUTE MYOCARDIAL INFARCTION IN DOGS : Myocardial metabolism Biochemistry : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- ANTIARRHYTHMIC EFFECTS OF EICOSAPENTAENOIC ACID DURING MYOCARDIAL INFARCTION : Enhanced Cardiac Microsomal(Ca^-Mg^)-ATPase Activity
- HIGHLY PURIFIED EICOSAPENTAENOIC ACID ATTENUATES TISSUE DAMAGE IN EXPERIMENTAL MYOCARDIAL INFARCTION
- A Consideration of a Mechanism of Augmentation of Peripheral Vascular Resistance in Hypertension : Presence of F-actin Filament in Renal Arterioles and Electrolytes Contents in Arterial Wall in Hypertensive Rat (Goldblatt Type)
- The 5'-Flanking Region of the Human Smooth Muscle Cell Calponin Gene Contains a cis-Acting Domain for Interaction with a Methylated DNA-Binding Transcription Repressor.