Altered Mechanical Properties in Smooth Muscle of Mice with a Mutated Calponin Locus(Physiology)
スポンサーリンク
概要
- 論文の詳細を見る
The mechanical properties of smooth muscles in aorta and vas deferens were studied in mice with a mutated basic calponin locus to learn the physiological function of calponin. The intact smooth muscles were stimulated with high KCl and the force development was compared between calponin deficient (knockout, KO) mice and wild type (WT) ones. The isometric force induced by various concentrations of high KCl was lower in KO than in WT both in aorta and in vas deferens. The length-force relations were compared between KO and WT. The active isometric force in KO was significantly lower at most muscle lengths examined than in WT without the change in resting force both in aorta and in vas deferens. In vas deferens, the rate of force development after quick release in length at the peak force was significantly faster in KO than in WT. The above results show that the force development is lower and the rate of crossbridge cycle is faster in KO mice than in WT ones, suggesting that calponin plays basic roles in the control of the contraction of smooth muscle.
- 社団法人日本動物学会の論文
- 2002-02-25
著者
-
Tsuchiya Teizo
Department Of Biology Faculty Of Science Kobe University
-
TAKAHASHI Katsuhito
Department of Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases
-
Fujishige Ayako
Department of Biology, Faculty of Science, Kobe University
-
Fujishige Ayako
Department Of Biology Faculty Of Science Kobe University
-
Takahashi Katsuhito
Department Of Medicine Osaka Medical Center For Cancer And Cardiovascular Diseases
-
Takahashi Katsuhito
Department Of Medicine Molecular Biology Unit Osaka Medical Center For Cancer And Cardiovascular Dis
関連論文
- Ca^-Sensitization of Contraction in the h1 Calponin-Deficient Smooth Muscle
- IS042 Mice lacking calponin display transdifferentiation of aortic smooth muscle into osteogenic-lineage cells that is associated with enhancement of bone morphogenetic protein responses
- Molecular Cloning and Characterization of Human Non-Smooth Muscle Calponin
- The 5'-Flanking Region of the Human Smooth Muscle Cell Calponin Gene Contains a cis-Acting Domain for Interaction with a Methylated DNA-Binding Transcription Repressor
- Sliding Movements of Molluscan and Algal Myosin Attached to a Magnetizable Bead under a Load Controlled by Electromagnet
- Sources of Activator Calcium Ions in the Contraction of Smooth Muscles in Aplysia kurodai(Physiology)
- The Influences of L(+)-Lactate and pH on Contractile Performance in Rabbit Glycerinated Skeletal Muscle
- FORCE ENHANCEMENT BY STRETCH OBSERVED IN A NERVE-SKELETAL MUSCLE PREPARATION(Cell Biology and Morphology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Structure and Expression of the Human SM22α Gene, Assignment of the Gene to Chromosome 11, and Repression of the Promoter Activity by Cytosine DNA Methylation
- The presence of h2-calponin in human keratinocyte
- The Effects of Temperature on the Mechanical Performance in Fatigued Single Muscle Fibers of the Frog Induced by Twitch and Tetanus
- Evidence for the Essential Role of Myosin Subfragment-2 in the ATP-Dependent Actin-Myosin Sliding in Muscle Contraction
- Altered Mechanical Properties in Smooth Muscle of Mice with a Mutated Calponin Locus(Physiology)
- Stretch-induced delayed force development in guinea-pig taenia coli.
- The 5'-Flanking Region of the Human Smooth Muscle Cell Calponin Gene Contains a cis-Acting Domain for Interaction with a Methylated DNA-Binding Transcription Repressor.