Role of DNA Damage in Cardiovascular Disease
スポンサーリンク
概要
- 論文の詳細を見る
Patients with some progeroid syndromes, such as Werner syndrome, exhibit atherosclerotic cardiovascular disease (CVD) at a young age as a manifestation of premature aging. Recent studies have revealed that most progeroid syndromes are caused by genetic defects in specific molecules involved in the DNA damage response, a cornerstone of genome stability. Ionizing radiation is one of the most potent genotoxic stimuli and causes various kinds of DNA damage. Further, there is increasing evidence that therapeutic radiation treatments can cause cardiovascular complications. Here, we describe the DNA damage and subsequent response, review recent advances in the understanding of the molecular basis of progeroid syndromes (especially those syndromes that involve CVD), review the pathological and epidemiological analysis of radiation-induced CVD, and discuss the possible role of DNA damage and the DNA damage response in the pathogenesis of atherosclerotic CVD.
- 一般社団法人 日本循環器学会の論文
著者
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Ishida Mari
Department Of Cardiovascular Physiology And Medicine Graduate School Of Biomedical Sciences Hiroshim
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Kihara Yasuki
Department Of Cardiology Graduate School Of Medicine Kyoto University
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Tashiro Satoshi
Department Of Biomedical Chemistry Hiroshima University Graduate School Of Biomedical Sciences
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Ishida Takafumi
Department Of Anthropology Faculty Of Science The University Of Tokyo
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Yoshizumi Masao
Department Of Cardiovascular Phisiology Graduate School Of Medicine Hiroshima University
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Ishida Takafumi
Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
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Kihara Yasuki
Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
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Yoshizumi Masao
Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
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Tashiro Satoshi
Department of Cellular Biology, Research Institute of Radiation Biology and Medicine, Hiroshima University
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Ishida Mari
Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
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Ishida Mari
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
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