レーザードップラー流速分布測定装置の生体計測への応用（皮膚癌の早期血流画像診断）

概要

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We intend to develop a laser Doppler velocimetry (LDV) system for in-vivo imaging that can measure blood flow velocity, that can generate tomograph of blood vessels with information in the depth direction and that has a high spatial resolution to enable individual microvessels. The present system evolved from a multipoint LDV (MLDV) that we developed for performing simultaneous multipoint measurements of water flow in transparent artificial flow channels. In this paper, we suggest an optical component of advanced MLDV for in-vivo and a method to determine the blood flow velocity from the sampling data. We measured microvessels of an experimental mouse, and succeeded in imaging the blood flow velocity in microvessels as 2 or 3 dimensional images. Finally, we demonstrate that using MLDV of blood vessels is useful for diagnosing malignant melanomas by comparison with visual diagnosis by dermoscopy.