Modified TPF Chemotherapy for Pulmonary Metastases from Squamous Cell Carcinoma of the Head and Neck

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We report herein on 15 cases of pulmonary metastases from squamous cell carcinoma of the head and neck (SCCHN) treated with modified TPF chemotherapy (docetaxel combined with nedaplatin and 5-FU). TPF chemotherapy is known as a neoajuvant chemotherapy regimen. We modified the TPF chemotherapy using nedaplatin as a substitute for cisplatin. We tried 4 courses of modified TPF chemotherapy every 3 weeks, docetaxel 60 mg/m2 on day 1; nedaplatin 75 mg/m2 on day 1 and 5-FU 1000 mg/body by continuous infusion on days 1 to 4. 11 patients received 4 courses, and the remaining of 4 patients recieved 1-3 courses because of their poor general condition. Of the 15 patients, 13 were males and 2 were females with ages ranging from 43 to 73 years (mean, 59.1 yr). Two of the primary sites were in the nasopharynx, 2 in orophanrynx, 4 in the hypopharynx, 2 in the larynx and 4 in the oral cavity. Clinically there were 7 complete responders, 4 partial responders, 2 with no change, and 2 with progressive disease. The mean overall survival was 46.5 months. TPF chemotherapy may improve the overall survival.