Significance of the perioperative measurement of brain natriuretic peptide (BNP) in general thoracic surgery

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Although arrhythmias are important complications occurring after general thoracic surgery, there have so far been few reports concerning the relationship between postoperative arrhythmias and the value of brain natriuretic peptide (BNP), which is thought to be an indicator of heart failure. We herein examine the perioperative BNP values and postoperative arrhythmias in general thoracic surgery.From January 2008 to May 2010, 63 patients (40 lobectomies, 15 wedge resections of the lung, 5 pneumonectomies, 3 mediastinal tumor resections) underwent general thoracic surgery at our hospital, and both the pre- and postoperative BNP levels were measured. Thereafter, the relationships among the BNP values, preoperative comorbidities, and postoperative arrhythmias were analyzed.Regarding the preoperative comorbidities, heart failure, ischemic heart disease, arrhythmia, and renal failure were all associated with increased preoperative BNP values. The BNP values in the patients with normal preoperative BNP values increased on postoperative day 1 and then decreased to normal levels for about one week. However, the BNP values in the patients with high preoperative BNP values decreased at a slower rate. In the 54 patients with preoperative BNP values below 100 pg/ml, the difference between the postoperative (day 1) and preoperative BNP values in patients who suffered from postoperative arrhythmias were significantly larger than that of the patients who did not experience postoperative arrhythmias, thus suggesting that the difference in the post- and preoperative BNP values may be an indicator of postoperative arrhythmia.

Significance of the perioperative measurement of brain natriuretic peptide (BNP) in general thoracic surgery

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