A case of acute hepatitis C with hepatitis C virus (HCV) genotype 3a -discussion of IL28-B-

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A 51-year-old man had a sexual relationship with a commercial sex worker in Thailand on a business trip. After returning to Japan, he saw a doctor because of fever and jaundice, feeling of fullness. He was admitted to the hospital because of liver dysfunction and abdominal dropsy on a diagnosis of acute hepatitis. Laboratory findings showed positive for anti-HCV as well as HCV RNA but negative for other virus markers. Thus he was diagnosed as having acute hepatitis C. Higher spontaneous clealance of HCV and sensitive for IFN therapy was expected due to HCV genotype 3a and IL28B (rs8099917) TT genotype. But he did not reach natural clealance of HCV. He was treated with pegylated interferon α2b and ribavirin therapy for 24weeks and attained sustained virological response finally. IL28B genotype assessment might be helpful in deciding the suitable management and treatment of acute HCV infection, but further accumulation and analyses of the future cases are necessary in the genotype 3.