Surgically Proven Normocalcemic Primary Hyperparathyroidism: Speculation of the Possible Role of Estrogen in the Etiology of this Disease in Premenopausal Women
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概要
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We herein report a rare case of surgically proven normocalcemic primary hyperparathyroidism (NCHPT). A premenopausal 51-year-old woman was referred to our clinic because parathyroid adenoma was detected on neck ultrasonography (US). The patient's serum calcium concentration was 9.3 mg/dL and the intact parathyroid hormone (PTH) level was 128.8 pg/mL. The findings of almost all other examinations were also compatible with a diagnosis of NCHPT. Then, parathyroidectomy was performed. The serum calcium and PTH concentrations reduced significantly but remained within the normal ranges. A histological examination demonstrated parathyroid adenoma. A review of this case and the associated literature suggests that estrogen plays a significant role in the etiology of NCHPT in premenopausal women.
著者
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Yamashita Hiroyuki
Department Of Collagen Disease National Center For Global Health And Medicine
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Sato Shinya
Department Of Animal Science Tokyo University Of Agriculture
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Tachibana Seigo
Department Of Endoclinology Noguchi Thyroid Clinic And Hospital Foundation
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Yanase Toshihiko
Department of Endocrinology and Diabetes Medicine, Fukuoka University Hospital, Japan
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Yokoi Tadao
Department of Surgery, Yamashita Thyroid and Parathyroid Clinic, Japan
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Sato Shinya
Department of Surgery, Yamashita Thyroid and Parathyroid Clinic, Japan
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