Whipple Disease Diagnosed with PCR Using Formalin-fixed Paraffin-embedded Specimens of the Intestinal Mucosa
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概要
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We herein present the case of a 54-year-old Japanese woman with Whipple disease diagnosed with polymerase chain reaction (PCR) using formalin-fixed paraffin-embedded (FFPE) specimens. The patient complained of weight loss, diarrhea and arthralgia. An endoscopic examination revealed swollen villi in the duodenum and ileum. Pathology demonstrated the presence of numerous macrophages filled with diastase-resistant PAS-positive particles. PCR using FFPE specimens amplified a fragment of 16S rDNA from Tropheryma whipplei. After the administration of ceftriaxone followed by trimethoprim/sulfamethoxazole, no signs of recurrence were observed for two years. The use of FFPE specimens for PCR should be considered for the prompt diagnosis and prevention of disease progression.
著者
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Yagihashi Soroku
Department of Molecular Pathology, Hirosaki University Graduate School of Medicine
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Chiba Daisuke
Department Of Advanced Prosthodontics Hiroshima University School Of Dentistry
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Ohkusu Kiyofumi
Department Of Microbiology Gifu University Graduate School Of Medicine
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Matsuzaki Yutaka
Department Of Metallurgy Graduate School Of Engineering Tohoku University
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WADA Ryuichi
Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine
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Yajima Nobuhisa
Department Of Pathology And Molecular Medicine Hirosaki University Graduate School Of Medicine
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Yagihashi Soroku
Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Japan
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Matsuzaki Yutaka
Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Japan
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Kimura Sotai
Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Japan
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Ebina Yoshihito
Department of Pathology, Kensei Hospital, Japan
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