Implication of proinfl ammatory reactions in pathogenesis of diabetic microvascular complications

概要

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Accumulating evidence supports that proinflammatory processes are implicated in the establishmentof characteristic pathology in diabetic vascular and neurological complications. Altered cellular signaling duringinflammatory processes is a new target for the treatment of diabetic complications and there appear to be someattempts to explore the eff ects of thiazolidinedione, a ligand of peroxisome proliferating activator receptor（ PPAR）-γfor not only the treatment of diabetes itself but for the application to diabetic complications. We therefore explored theeff ects of PPAR-γ agonist, pioglitazone, on the experimental model of diabetic neuropathy. We found that pioglitazonesignifi cantly improved nerve conduction velocities and depressed protein kinase C activity. This is a new area for theexploration of eff ective treatment of diabetic complications that pose a considerable socioeconomic burden in the currentworld.
弘前大学の論文