Clinicopathological Analysis of Glomerulopathy with Fibronectin Deposits (GFND): A Case of Sporadic, Elderly-Onset GFND with Codeposition of IgA, C1q, and Fibrinogen
スポンサーリンク
概要
- 論文の詳細を見る
A 67-year-old Japanese man with recurrent nephrotic syndrome and impaired kidney function had a sporadic, elderly-onset case of glomerulopathy with fibronectin deposits. The daily urinary protein, serum albumin, blood urea nitrogen, and creatinine levels were 3.6 g/day, 2.7 g/dL, 19.5 mg/dL, and 1.70 mg/dL, respectively. Kidney biopsy samples were evaluated using electron microscopy and demonstrated membranoproliferative glomerulonephritis-like lesions with massive subendothelial depositions and no fibrillary structures. Immunofluorescent studies showed 1+ staining for IgA, C1q, and fibrinogen. Anti-fibronectin immunostaining demonstrated that the subendothelial deposits were positive for fibronectin. The administration of prednisolone and mizoribine improved the nephrotic syndrome.
著者
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Suzuki Keisuke
Division of Cardiology, Hematology and Endocrinology
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Kitagawa Wataru
Division Of Nephrology And Rheumatology Department Of Internal Medicine Aichi Medical University Sch
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Ohnishi Takahiro
Division Of Cardiology Yamada Red Cross Hospital
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Miura Naoto
Division Of Nephrology And Rheumatology Department Of Internal Medicine Aichi Medical University Sch
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Imai Hirokazu
Division Of Nephrology And Rheumatology Department Of Internal Medicine Aichi Medical University Sch
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Nishikawa Kazuhiro
Division Of Nephrology And Rheumatology Department Of Internal Medicine Aichi Medical University Sch
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Yoshino Masabumi
Division Of Nephrology And Rheumatology Department Of Internal Medicine Aichi Medical University Sch
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Yoshino Masabumi
Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Japan
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