Effects of Pitavastatin in Japanese Patients With Chronic Heart Failure:– The Pitavastatin Heart Failure Study (PEARL Study) –
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概要
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Background: Recent clinical trials using rosuvastatin, a hydrophilic statin, did not show beneficial effects on cardiovascular events in patients with heart failure. We examined the cardioprotective effects of pitavastatin, a lipophilic statin, on Japanese patients with chronic heart failure (CHF). Methods and Results: A total of 574 Japanese patients with CHF were randomly assigned to the pitavastatin group (n=288) or the control group (n=286). There was no significant difference between the 2 groups for the primary outcome, which was a composite of cardiac death and hospitalization for worsening HF (adjusted hazard ratio (aHR): 0.922, 95% confidence interval (CI): 0.632–1.345, P=0.672). A strongly significant statistical interaction between the effect of pitavastatin and left ventricular ejection fraction (LVEF) was found (P=0.004). In patients with LVEF ≥30%, a significant reduction in the primary outcome (aHR: 0.525, 95% CI: 0.308–0.896, P=0.018) was observed in the pitavastatin group. Pitavastatin did not show any effects on the primary outcome (aHR: 1.582, 95% CI: 0.890–2.813, P=0.118) in the subgroup of patients with LVEF <30%. Conclusions: Pitavastatin did not reduce cardiac death or hospitalization for worsening HF in Japanese patients with CHF. (UMIN-ID: UMINC000000428). (Circ J 2013; 77: 917–925)
著者
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Kobayashi Yoshio
Department of Biomolecular Functional Engineering, College of Engineering, Ibaraki University
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Inoue Teruo
Department Of Cardiology Koshigaya Hospital Dokkyo University School Of Medicine
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Kuwabara Yoichi
Department Of Cardiology Tokyo Medical University
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Fujimatsu Daisuke
Department Of Cardiovascular And Renal Medicine Saga University
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Kotooka Norihiko
Department Of Cardiovascular And Renal Medicine Saga University
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Mizuma Hiroshi
Department Of Cardiology Chiba Cardiovascular Center
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Sato Yasunori
Clinical Research Center Chiba University Hospital
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Node Koichi
Department Of Cardiovascular & Renal Disease Medicine Saga University
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Takano Hiroyuki
Department Of Bio-medical Engineering Tokai University School Of High-technology For Human Welfare
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Komuro Issei
Department Of Cardiovascular Medicine
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Takano Hiroyuki
Department of Molecular Cardiovascular Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University
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Shindo Satoshi
Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine
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Kobayashi Yoshio
Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine
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Kobayashi Yoshio
Department Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
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