Synthesis and Cytotoxicity on Human Leukemia Cells of Furonaphthoquinones Isolated from Tabebuia Plants
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概要
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Furonaphthoquinones are promising skeletons for anticancer drug molecules. In particular, methoxylated furonaphthoquinones are characteristic constituents of Tabebuia plants. In this research, we synthesized the furonaphthoquinones by effective one-pot cascade reactions of 3-phenyliodonio-1,2,4-trioxo-1,2,3,4-tetrahydronaphthalenides with 3-butyn-2-ol in the presence of palladium and cuprous catalysts via Sonogashira coupling and intramolecular cyclization. Furthermore, we demonstrated that the synthetic furonaphthoquinones showed moderate cytotoxicity against human leukemia U937 and HL-60 cells. Our work highlights the importance of furonaphthoquinones as antileukemic agents.
著者
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Tanaka Kaori
Division Of Anaerobe Research Life Science Research Center Gifu University
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Koketsu Mamoru
Department Of Chemistry Faculty Of Engineering Gifu University
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Watanabe Kunitomo
Division Of Anaerobe Research Life Science Research Center Gifu University
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Ninomiya Masayuki
Department Of Materials Science And Technology Faculty Of Engineering Gifu University
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TANAKA Kaori
Division of Anaerobe Research, Life Science Research Center, Gifu University
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Inagaki Ryuta
Department of Materials Science and Technology, Faculty of Engineering, Gifu University
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