Studies on the Jaffé Reaction of Hydantoin Compounds and Cyclization of the Carbamyl Compounds by Dehydration.

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The Cyclization of N-carbomyl-α-alanine, and N-carbomylglycine by the treatment with hydrochloric acid was Investigated by means of the Jaffé reaction and Fearon reaction. Effect of the corresponding hydantoin compounds produced on Velocity and Coloration in the Jaffé reaction were compared. The results thus were as follows: 1. The Jaffe reaaction proceeded more rapidly and the color from 1-methyl hydantoin developed more storongly than that from hydantoin. 2. The Jaffe reaction of 1-methyl hydantoin proceededs more sluggishly than that of creatinine. 3. 5-methylhydantoin, the product from N-carbamyl-α-alanine, hardly reacts with the Jaffe reagent. 4. There is no differance in absorptionspectra in the visible range among the complexs of the Jaffe reagent with creatinine, hydantoin and 1-methylhydantoin. 5. N-carbamyl-glycine was very difficult to cyclization product when heated under the acidic condition.
Japan Society of Clinical Chemistryの論文