Regulatory Function of Portal Blood in Energy Balance of Damaged Livers

概要

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Information has been obtained concerning the extracellular control of energy metabolism of liver by changing portal blood supply.<BR>For this purpose, male adult rabbits were used for the following three different surgical treatments: (1) ligation of left portal branch (60% segment),(2) portacaval shunt (side to side anastomosis) and (3) combination of portal branch ligation with portacaval shunt.<BR>(1) In the ligated lobe with portal blood supply only from the hepatic artery, it was seen that both activities of energy generation and utilization markedly decreased coordinately, in spite of a higher level of energy charge being shown, which is considered to arise from the result that ATP utilization was more depressed than generation.<BR>(2) Reduction of portal blood flow via portal vein following anastomosis resulted in light atrophy of the whole liver, in a similar way to the energy balance shown in the ligated lobe.<BR>(3) However, an increased portal blood supply via hepatic artery into the ligated lobe inhibited the atrophic alteration of the ligated lobe brought about in the first type of operation.