INDUCTION OF HYPERURICEMIC STATE AND ELEVATION OF THE LIVER 5-PHOSPHORIBOSYL-1-PYROPHOSPHATE (PRPP) LEVELS BY XYLITOL AND FRUCTOSE ADMINISTRATION IN MICE

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A pronounced hyperuricemic state was induced, peaked at 30 min, after intraperitoneal administration of xylitol or fructose at a dose of 0.5 g/kg in male mice. The level of uric acid increased more after xylitol than after an equivalent dose of fructose.<BR>Xylitol and fructose markedly elevated the liver PRPP levels, peaked at 15 min, after the intraperitoneal administrations in mice. Increase in the PRPP level after xylitol injection was dose-dependent and much higher than that after fructose. However, the PRPP levels in the erythrocytes were not changed or rather decreased by xylitol or fructose injection.<BR>On the other hand, no substantial increase of both the liver PRPP and serum urate level was found by glucose administration.<BR>Xylitol-induced elevation of the liver PRPP was not due to stimulation of insulin release by this compound, because this response was also observed in the alloxan-treated mice.<BR>These observations suggest that not only stimulate d degradation of ATP but also enhanced PRPP level followed by stimulation of purine de novo synthesis in the liver may play an important role in the mechanism of hyperuricemia induced by xylitol and fructose.
Japanese Society of Gout and Nucleic Acid Metabolismの論文