A Case of Myelocytic Leukemia associated with Hypouricemia
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A 62-year old man was admitted to this hospital with fever and gingival bleeding.<BR>On admission, the white blood cell (WBC) count was 10,200/mm<SUP>3</SUP>,92% of which being myeloblasts. The serum uric acid (SUA) level was 3.2 mg/dl. After the administration of antileukemic agents, the SUA level decreased to 0.9 mg/dl at minimum with the decrease of WBC, and at that time the urinary excretion of urate and the uric acid clearance (C<SUB>UA</SUB>) was about 900mg/day and 25.6 ml/min respectively. However, the SUA level and C<SUB>UA</SUB> returned to normal during remission.<BR>The above results indicate that impaired tubular dysfunction was the main factor responsible for the fall in the SUA level.
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