Clinical Features and Hepatitis B Virus (HBV) Genotypes in Pregnant Women Chronically Infected with HBV
スポンサーリンク
概要
- 論文の詳細を見る
Objective The purpose of this study was to clarify the clinical features and hepatitis B virus (HBV) genotypes in pregnant women chronically infected with HBV. Methods Among 1,489 pregnant women who visited our hospital in 2010, 26 were positive for hepatitis B surface antigens (HBsAg). Of these subjects, 21 from whom informed consent was obtained were included in this study. The clinical features and HBV markers, including genotypes, were investigated. Results No adverse events were observed in the subjects or the neonates during pregnancy or the perinatal period. The HBV genotypes were C in 14 cases, D in six cases, and undetermined in one case. Hepatitis B e antigens and a high viral load (>7.0 log copies/mL) were found in four and six subjects with genotype C, respectively, and in none of subjects with genotype D. The alanine aminotransferase (ALT) levels and platelet counts were within the normal ranges during pregnancy in all subjects except two and three subjects with genotype C, respectively. Three subjects with genotype C showed transient elevations of ALT after delivery. Conclusion The majority of subjects were anti-HBe-positive with normal ALT levels; however, some subjects with genotype C showed a high viral load, elevated ALT levels and/or low platelet counts. The pregnancies and deliveries were safe; however, transient elevations of ALT after delivery were observed in some subjects with genotype C.
著者
-
Horiike Norio
Department Of Gastroenterology And Metabology Ehime University Graduate School Of Medicine
-
Ochi Hiroshi
Department Of Clinical Bio-regulatory Science Division Of Molecular Medicine For Adult And Geriatric
-
Hiasa Yoichi
Department Of Gastroenterology And Metabology Ehime University Graduate School Of Medicine
-
Onji Morikazu
Department Of Gastroenrerology And Metabology Ehime University Graduate School Of Medicine
-
Abe Emiko
Department Of Applied And Environmental Chemistry Kitami Institute Of Technology
-
Abe Masanori
Department Of Anesthesiology Faculty Of Medicine University Of The Ryukyus
-
Abe Emiko
Department of Obstetrics and Gynecology, Ehime Prefectural Central Hospital, Japan
-
Michitaka Kojiro
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
-
Hiraoka Atsushi
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
-
Imai Yusuke
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
-
Utsunomiya Hiroki
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
-
Tatsukawa Haruka
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
-
Shimizu Yuko
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
-
Ninomiya Keiko
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
-
Yamago Hiroka
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
-
Tanihira Tetsuya
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
-
Hasebe Aki
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
-
Ninomiya Tomoyuki
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
-
Onji Morikazu
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
-
Hiasa Yoichi
Department of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan
-
Ochi Hiroshi
Department of Obstetrics and Gynecology, Ehime Prefectural Central Hospital, Japan
関連論文
- Guidelines for the antiviral therapy of hepatitis C virus carriers with normal serum aminotransferase based on platelet counts
- Spatial and chronological differences in hepatitis B virus genotypes from patients with acute hepatitis B in Japan
- The efficacy of ursodeoxycholic acid and bezafibrate combination therapy for primary biliary cirrhosis : A prospective, multicenter study
- Impaired dendritic cell functions disrupt antigen-specific adaptive immune responses in mice with nonalcoholic fatty liver disease
- Effects of antihyperlipidemic agents on hepatic insulin sensitivity in perfused Goto-Kakizaki rat liver
- Predictive values of amino acid sequences of the core and NS5A regions in antiviral therapy for hepatitis C : a Japanese multi-center study
- Hepatitis B virus genotype G is an extremely rare genotype in Japan
- Primitive Neuroectodermal Tumor of the Pancreas
- A 1.2 Gbps wireless LAN system for 4K digital cinema transmission (スマートインフォメディアシステム)
- A Study on Channel Estimation Using Two-Dimensional Interpolation Filters for Mobile Digital Terrestrial Television Broadcasting
- Design of single carrier wireless system with frequency domain equalizer (音声)
- Design of single carrier wireless system with frequency domain equalizer (スマートインフォメディアシステム)
- Design of single carrier wireless system with frequency domain equalizer (信号処理)
- PROTEIN KINASE C-INDEPENDENT MECHANISMS OF ENDOTHELIAL PDGF-B CHAIN mRNA INDUCTION BY LYSOPHOSPHATIDYLCHOLINE
- Engineering immune therapy against hepatitis B virus
- Induction and maintenance of anti-HBs in immunosuppressed murine hepatitis B virus carriers by a novel vaccination approach : implications for use in hepatitis B virus-infected subjects with liver transplantation
- Primary hepatic marginal zone B cell lymphoma of mucosa-associated lymphoid tissue type : case report and review of the literature
- Hepatic Encephalopathy Due to Intrahepatic Portosystemic Venous Shunt Successfully Treated by Interventional Radiology
- Characteristic endoscopic features of portal hypertensive enteropathy
- Coexistent myelodysplastic syndrome and non-Hodgkin lymphoma. Report of a casa and review of the literatura
- Recent clinical features of Wilson's disease with hepatic presentation
- LAPAROSCOPIC FINDINGS OF LIVER CIRRHOSIS DUE TO NON-ALCOHOLIC STEATOHEPATITIS
- Gianotti-Crosti Syndrome Caused by Acute Hepatitis B Virus Genotype D Infection
- EFFICACY OF LAPAROSCOPIC RADIOFREQUENCY ABLATION FOR HEPATOCELLULAR CARCINOMA COMPARED TO PERCUTANEOUS RADIOFREQUENCY ABLATION WITH ARTIFICIAL ASCITES
- Efficacy of splenectomy for hypersplenic patients with advanced hepatocellular carcinoma
- Neuropsychiatric dysfunction in patients with chronic hepatitis and liver cirrhosis
- Protective role of interleukin-10-producing regulatory dendritic cells against murine autoimmune gastritis
- LAPAROSCOPIC FEATURES AND INTEROBSERVER VARIATION OF HISTOLOGICAL DIAGNOSIS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE
- Clinical usefulness of quantitative evaluation of visceral fat by ultrasonography
- Percutaneous ultrasound-guided radiofrequency ablation of hepatocellular carcinoma with artificially induced pleural effusion and ascites
- Clinical features of symptomatic primary biliary cirrhosis initially complicated with esophageal varices
- Clinical characteristics of autoimmune hepatitis in older aged patients
- Molecular characterization and distribution of motilin family receptors in the human gastrointestinal tract
- Earlier recurrence of esophageal varices, following therapy, in patients with primary biliary cirrhosis (PBC) compared with non-PBC patients
- Renal Transplant Recipient with Chronic Hepatitis C Who Obtained Sustained Viral Response after Interferon-β Therapy
- CASE OF AIDS-RELATED CHOLANGITIS TREATED BY ENDOSCOPIC SPHINCTEROTOMY
- Hepatopulmonary Syndrome in a Patient with Primary Biliary Cirrhosis
- Esophagogastric varices as a prognostic factor for the determination of clinical stage in patients with primary biliary cirrhosis
- Doppler Waveform Pattern Changes in a Patient with Primary Budd-Chiari Syndrome before and after Angioplasty
- Budd-Chiari Syndrome Associated with Hypereosinophilic Syndrome; A Case Report
- A High Throughput Medium Access Control Implementation Based on IEEE 802.11e Standard
- Toll-Like Receptor 3 Signaling Induces Chronic Pancreatitis through the Fas/Fas Ligand-Mediated Cytotoxicity
- Bronchial and nasal responsiveness in atopic asthma and allergic rhinitis patients: Relationship of local responsiveness to cytokine production by peripheral blood monounclear cells
- Prevention of hepatitis B virus infection by vaccination : Progress and problems
- Zinc and hepatitis B virus vaccination
- Changes in gastrointestinal lymph and blood vessels in patients with cirrhotic portal hypertension
- Clinical characteristics of autoimmune hepatitis with histological features of acute hepatitis
- Characteristics of geographic distributions and route of infection for hepatitis B virus genotype D in Ehime area in western Japan
- Therapeutic efficacy of decreased nitrite production by bezafibrate in patients with primary biliary cirrhosis
- Change of acute hepatitis B transmission routes in Japan
- Autoimmune Hepatitis Associated with Graves' Disease
- Changes in serum concentrations of tumor necrosis factor α and adhesion molecules in normal pregnant women and those with pregnancy-induced hypertension
- Progressive Transmission of Continuous Tone Images Using Multi-Level Error Diffusion Method
- Etiology of liver cirrhosis in Japan : a nationwide survey
- Diabetes mellitus reduces the therapeutic effectiveness of interferon-α2b plus ribavirin therapy in patients with chronic hepatitis C
- Drug-induced Hepatitis due to Repeated Use of Hair Dye
- Hepatic senescence marker protein-30 is involved in the progression of nonalcoholic fatty liver disease
- Liver/spleen volume ratio as a predictor of prognosis in primary biliary cirrhosis
- Small Hepatocellular Carcinoma Associated with Wilson's Disease
- Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis C virus infection for the fiscal year 2008 in Japan
- Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis B virus infection for the fiscal year 2008 in Japan
- Amino acid imbalance in patients with chronic liver diseases
- Usefulness of the hyperechoic rim for assessing the therapeutic efficacy of radiofrequency ablation in hepatocellular carcinoma patients
- Early biochemical response to ursodeoxycholic acid predicts symptom development in patients with asymptomatic primary biliary cirrhosis
- Autoimmune hepatitis showing spontaneous remission and acute exacerbation
- Drug-induced liver injury in Japan : An analysis of 1676 cases between 1997 and 2006
- Natural history of primary biliary cirrhosis
- Understanding the precise function of interferon regulatory factor 3 in hepatitis C virus replication will lead to a new strategy for therapy
- Prevalence of hepatitis E virus among wild boar in the Ehime area of western Japan
- Inability of liver dendritic cells from mouse with experimental hepatitis to process and present specific antigens
- Hepatocellular Carcinoma in a Case of Wilsons Disease Treated with Radiofrequency Ablation Therapy
- Soluble CD163 in patients with liver diseases : very high levels of soluble CD163 in patients with fulminant hepatic failure
- Decompensated Hepatitis B Virus-related Cirrhosis Successfully Treated with Lamivudine Allowing Surgery for Hepatocellular Carcinoma
- Morphometric analysis of lymphatic vessels in primary biliary cirrhosis
- Anti-HBs-Positive Liver Failure Due to Hepatitis B Virus Reactivation Induced by Rituximab
- Dendritic cell subtypes in autoimmune liver diseases ; decreased expression of HLA DR and CD123 on type 2 dendritic cells
- Effect of mutation in the hepatitis C virus nonstructural 5B region on HCV replication
- Accumulation of refractory factors for pegylated interferon plus ribavirin therapy in older female patients with chronic hepatitis C
- GENERAL RULES FOR RECORDING ENDOSCOPIC FINDINGS OF ESOPHAGOGASTRIC VARICES (2ND EDITION)
- Factors predictive of sustained virological response following 72 weeks of combination therapy for genotype 1b hepatitis C
- Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease
- Future aspects of therapy for hepatitis B virus infection : value of surrogate markers, innovative therapy, and global collaboration
- Changes of anthropometric and biological parameters in patients with non-alcoholic steatohepatitis for dietary modification
- CONGENITAL HEPATIC FIBROSIS WITHOUT ANY SYMPTOMS AS DIAGNOSED BY LAPAROSCOPY
- Brain Metastasis from Hepatocellular Carcinoma Treated with a Cyber-Knife
- Effect of pioglitazone on various parameters of insulin resistance including lipoprotein subclass according to particle size by a gel-permeation high-performance liquid chromatography in newly diagnosed patients with type 2 diabetes
- Delayed Lattice Reduction Algorithm for High Performance MIMO Decoder
- Ulcerative Colitis Complicated with Primary Biliary Cirrhosis
- RTL Design of High-Speed Sorted QR Decomposition for MIMO Decoder
- Huge Pancreatic Acinar Cell Carcinoma with High Levels of AFP and Fucosylated AFP (AFP-L3)
- Metabolic markers and ALT cutoff level for diagnosing nonalcoholic fatty liver disease : a community-based cross-sectional study
- Clinical Features and Hepatitis B Virus (HBV) Genotypes in Pregnant Women Chronically Infected with HBV
- Colonic Intussusception Caused by Anisakiasis: A Case Report and Review of the Literature
- Novel THP Scheme with Minimum Noise Enhancement for Multi-User MIMO Systems
- Three Cases of Liver Abscesses Complicated with Colon Cancer without Liver Metastasis: Importance of Screening for Digestive Disease
- Development of Hepatocellular Carcinoma (HCC)in a Patient 17 Years after Recovery from ChronicHepatitis B and Seroconversion to Anti-HBs
- Portal Biliopathy Diagnosed Using Color Doppler and Contrast-enhanced Ultrasound
- Clinical Course of Tuberculous Peritonitis Determined by Laparoscopy
- Clinical Characteristics of Patients who Developed Hepatocellular Carcinoma after Hepatitis C Virus Eradication with Interferon Therapy: Current Status in Japan
- Sustained virological response of patients with hepatitis C virus genotype 2 depends on pegylated interferon compliance