Anti-HBs-Positive Liver Failure Due to Hepatitis B Virus Reactivation Induced by Rituximab
スポンサーリンク
概要
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A 59-year-old man developed acute hepatitis with reactivated hepatitis B virus (HBV) following administration of rituximab (anti-CD20 monoclonal antibody). The patient was diagnosed with malignant lymphoma in 1998, and virus marker testing indicated HBV surface antigen (HBsAg)-negative and anti-HBs antibody (anti-HBs)-positive results when chemotherapy including rituximab was started. Levels of aminotransferases were elevated, and HBsAg results turned positive. Despite therapy for late-onset hepatic failure, the patient died. Rituximab appears likely to have induced HBV reactivation in this case. Anti-viral agents should be administered for both HBsAg-positive and anti-HBs-positive patients who are scheduled to receive rituximab.
著者
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Matsuura Bunzo
Department Of Gastroenterology And Metabology Ehime University Graduate School Of Medicine
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Konishi Ichiro
Department Of Gastroenterology And Metabology Ehime University Graduate School Of Medicine
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Horiike Norio
Department Of Gastroenterology And Metabology Ehime University Graduate School Of Medicine
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TOKUMOTO Yoshio
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
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Matsuura Kana
Department Of Gastroenterology And Metabology Ehime University Graduate School Of Medicine
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Onji Morikazu
Department Of Gastroenrerology And Metabology Ehime University Graduate School Of Medicine
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Michitaka Kojiro
Department of Endoscopic Medicine, Ehime University Graduate School of Medicine
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Hiasa Yoichi
Department of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan
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Tokumoto Yoshio
Department of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan
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Sera Toshiki
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
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Matsuura Bunzo
Department of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan
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