Influence of the Digested Products of Royal Jelly on Insulin Levels in KK-Ay Mice
スポンサーリンク
概要
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Aspergillus niger protease digest of royal jelly (royal jelly peptides) was administered to KK-Ay diabetic mice for 35 days. Oral administration of a high dose (350 mg/kg) of royal jelly peptides suppressed increases in blood glucose levels similar to extract of guava leaves, an α-amylase inhibitor. This effect appears to be due to a decrease in food intake and subsequent reduction in body weight. In mice with free access to diet containing royal jelly peptides at 0.18 w/w%, no effect on blood glucose levels, blood triglyceride levels, food intake and body weight were found. However, an increase in blood insulin levels was observed. This suggests that royal jelly peptides may increase insulin levels without affecting blood glucose levels and food intake.
著者
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Yoshizaki Fumihiko
Department Of Pharmacognosy Tohoku Pharmaceutical University
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Kobayashi Kyoko
Department Of Anesthesiology And Intensive Care Medicine Graduate School Of Medical Science Kanazawa
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HITOMI Nobuyuki
R&D Center, Japan Royal Jelly Co., Ltd.
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MURATA Kiyoshi
R&D Center, Japan Royal Jelly Co., Ltd.
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YOSHIZAKI Hiroshi
R&D Center, Japan Royal Jelly Co., Ltd.
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YAMAGUCHI Kikuji
Head office, Japan Royal Jelly Co., Ltd.
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MURATA Kiyoshi
R&D Center, Japan Royal Jelly Co., Ltd.
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HITOMI Nobuyuki
R&D Center, Japan Royal Jelly Co., Ltd.
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KOBAYASHI Kyoko
Department of Pharmacognosy, Tohoku Pharmaceutical University
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