急性肩石灰性腱炎の病理学的解析

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Background: We performed arthroscopic surgery for acute calcific tendinitis of the shoulder to compare JOA scores before and after surgery. In addition, histological analysis of calcified cuff tissue was performed to investigate the pathology of the acute phase of the disease. Methods: Calcified cuff tissues were examined from six patients with acute calcific tendinitis of the shoulder with a mean age of 54.2 years old. Calcified cuff tissues were stained with hematoxylin and eosin (H.E.) and examined using immunohistochemical staining. TNF-α, interleukin-6 (IL-6), matrix metalloproteinase (MMP)-3, S-100 protein, vascular endothelial growth factor (VEGF) and specific staining, sudan III (lipid), alizarin red (calcium), rubean coper (Cu), congo red (amyloid), berlin blue (Fe), and uric acid (UA) were analyzed by the use of the methods of Hand et al, to detect expression patterns. Results: H.E. showed defect spots of calcium deposit with few cell proliferations in calcified cuff tissues. TNF-α was positive in 16.7 % (1/6)of cases, however IL-6 and MMP-3 were negative. S-100 protein was positive in 83.3 % and VEGF was positive in 16.7 % of cases. sudan III (lipid) was positive in 83.3 % of cases, however alizarin red (calcium), rubean coper (Cu), congo red (amyloid), berlin blue (Fe), uric acid (UA) were negative in calcified cuff tissues. Conclusion: Arthroscopic resection of calcified tissue in acute calcifying tendinitis of the shoulder was not sufficiently effective, however there was statically significant efficacy. TNF-α, S-100 protein and lipid deposits were observed in calcified cuff tissues of acute calcifying tendinitis of the shoulder.

急性肩石灰性腱炎の病理学的解析

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