Ascorbic Acid Levels in Various Tissues, Plasma and Urine of Mice during Aging
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概要
- 論文の詳細を見る
Here we quantified ascorbic acid (AA) levels in 14 tissues, plasma and urine of C57BL/6 male mice to track its turnover during 3 to 30 mo of aging. The AA content of adrenal glands and testes decreased somewhat with age, and eventually rose, but increased in the spleen, lungs, eyes and heart. AA levels rose in the liver, skin and skeletal muscles from 6 to 12 mo of age, but declined from 12 to 24 mo. In the cerebellum, cerebrum, small intestine, kidney and plasma, amounts of AA remained almost constant as the animals aged. Most notably, urinary AA decreased markedly until becoming almost undetectable at 24 and 30 mo of age. Collectively, these results, which compare changes in AA levels in specific physiologic targets throughout the aging process, strongly suggest that the AA synthesizing capacity declines over time to become a major factor in senescence-related diseases.
- 日本ビタミン学会、日本栄養・食糧学会の論文
著者
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Amano Akiko
Aging Regulation Tokyo Metropolitan Institute Of Gerontology
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Amano Akiko
Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology
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Ishigami Akihito
Molecular Regulation Of Aging Tokyo Metropolitan Inst. Of Gerontology
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Iwama Mizuki
Molecular Regulation Of Aging Research Team For Functional Biogerontology Tokyo Metropolitan Institu
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Maruyama Naoki
Molecular Regulation Of Aging Research Team For Functional Biogerontology Tokyo Metropolitan Institu
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Shimokado Kentaro
Department Of Geriatric And Vascular Medicine Tokyo Medical And Dental University
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IWAMA Mizuki
Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology
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