Uric Acid Levels in Tissues and Plasma of Mice during Aging
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概要
- 論文の詳細を見る
Here we quantified the uric acid (UA) levels in 11 tissues and plasma of C57BL/6 male mice to track its turnover during 3 to 30 months of aging. UA levels in the adrenal glands, heart, and spleen increased with aging until 30 months of age. Similarly, UA levels in the liver, kidneys, pancreas, and testes increased until the mice were 24 months old. UA levels also rose in the lungs and skeletal muscles from 3 to 6 months and 6 to 12 months, respectively, and then remained at almost the same levels until 30 months of age. In the skin, UA decreased from 3 to 6 months and then stayed nearly constant until 30 months of age. Moreover, the small intestines and plasma had quite stable UA levels during aging. Thus, our assessment of 11 tissue types from mice showed that the UA levels increased in most tissues during aging.
- 公益社団法人 日本薬学会の論文
著者
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KONDO Yoshitaka
Tokyo Metropolitan Institute of Gerontology
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Kondo Yoshitaka
Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology
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Ishigami Akihito
Molecular Regulation Of Aging Tokyo Metropolitan Inst. Of Gerontology
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Iwama Mizuki
Molecular Regulation Of Aging Research Team For Functional Biogerontology Tokyo Metropolitan Institu
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Maruyama Naoki
Molecular Regulation Of Aging Research Team For Functional Biogerontology Tokyo Metropolitan Institu
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Shimokado Kentaro
Department Of Geriatric And Vascular Medicine Tokyo Medical And Dental University
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