Angioedema of the Periorbital Region that Developed during Treatment with Etanercept in a Case of Refractory Adult-Onset Still's Disease
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概要
- 論文の詳細を見る
A 78-year-old Japanese man with adult-onset Still's disease that was refractory to conventional treatment, such as prednisolone (PSL) concomitant with methotrexate (MTX). Etanercept (50 mg/week) was added to PSL (12.5 mg/day) and MTX (12 mg/week). His manifestation improved dramatically, nonetheless massive edema of the periorbital region developed by the fourth injection, which kept his palpebral fissure completely closed. There was also a marked injection site reaction to etanercept. A diagnosis of angioedema due to etanercept was thus made, and the drug was discontinued. His angioedema began to ameliorate soon after antihistamines were introduced without any critical involvement, such as laryngeal obstruction.
著者
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Nobuhara Mamoru
Department Of Cardiology Hamamatsu Rosai Hospital
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Ohashi Hiroyuki
Department Of Astronomy Kyoto University
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Ogawa Noriyoshi
Division Of Hematology And Immunology Department Of Internal Medicine Kanazawa Medical University
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Takahashi Satoru
Department Of Anatomy And Embryology Biomolecular And Integrated Medical Sciences Graduate School Of
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Kato Takashi
Department Of Applied Chemistry Graduate School Of Engineering Nagoya Institute Of Technology
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Uehara Masahiro
Department of Electrical Engineering, Kisarazu National College of Technology
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Uehara Masahiro
Department of Internal Medicine, Omaezaki Municipal General Hospital, Japan
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Ogawa Noriyoshi
Division of Rheumatology, Department of the Third Internal Medicine, Hamamatsu University School of Medicine, Japan
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Kato Takashi
Department of Internal Medicine, Omaezaki Municipal General Hospital, Japan
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Noguchi Kei
Department of Ophthalmology, Omaezaki Municipal General Hospital, Japan
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Kisamori Yumi
Department of Internal Medicine, Omaezaki Municipal General Hospital, Japan
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Ikegaya Hideki
Department of Internal Medicine, Omaezaki Municipal General Hospital, Japan
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Nobuhara Mamoru
Department of Internal Medicine, Omaezaki Municipal General Hospital, Japan
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