In vitro Effects of Glycyrrhizin on the Serum Enzymes in Chronic Hepatitis Patients

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In vitro effects of glycyrrhizin on the serum enzymes in chronic hepatitis patients were studied. Forty μg and 100 μg of glycyrrhizin per one ml of reaction mixture inhibited transaminase activity by about 10% and 32-37%, respectively, in a noncompetitive manner. The former concentration was comparable to the clinical dose by intravenous administration in the treatment of liver diseases. Glycyrrhizin also had inhibitory action on the activities of serum LDH and LAP, but not on MAO activity. Furthermore, this agent exhibited activation on acid RNase, but not on alkaline RNase.