Efficacy of Diltiazem on 24-Hour Blood Pressure Profile in Essential Hypertension.

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The aim of this study was to assess the efficacy of diltiazem monotherapy on deviant blood pressure (BP) profiles of essential hypertension.METHODS: 30 or 60mg of diltiazem was administered three times a day for 4wk. 13 untreated patients with essential hypertension were monitored by an ambulatory blood pressure monitoring device (ABPM-630, Nippon Colin, Japan) for 48hr before and during the treatment. BP data were analyzed with the conventional statistical and cosinor method for rhythmometory. The deviant pressure was quantified as pressure-time magnitude (hyperbaric index) compared with 90% reference interval matched for age and gender of our 334 individuals.RESULTS AND CONCLUSIONS: Diltiazem was revealed to have an antihypertensive effect on the circadian profile in essential hypertension. The mean of systolic and diastolic BP of 48hr decreased from 148±12mmHg to 132±8mmHg and from 87±9mmHg to 76±6mmHg, respectively (P<0.001). The hyperbaric index of systolic and diastolic BP significantly decreased (P<0.01). The mean of heart rate of 48 hours showed no significant change. The hyperbaric index of BP significantly decreased during the night resting span.