培養ヒト関節構成細胞に対するHe-Neレ-ザ-の影響

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We have already reported the observation that He-Ne laser irradiation applied to adjuvant arthritis of rats causes fibrosis and reduces blood vessels in the synovium. In the recent study, we applied 50 to 1500mJ/cm2 a day of He-Ne laser irradiation to cultured vascular endothelial cells (EC) from the umbilical cord vein, synovial cells (SC), and chondrocytes (Ch) for three days. Except for a suppression to Ch by 1500mJ/cm2 a day of irradiation, no significant influence was found on DNA synthesis in EC and SC.The concentration of von Willebrand factor and fibronectin in the culture supernatant of EC, and of fibronection from SC, however, increased significantly after laser irradiation. This indicated that the effects of He-Ne laser irradiation on the cultured cells in vitro differed from those obtained in our previous experiment in vivo, and biostimulatory effects of He-Ne laser on cultured cells were observed as described above.
一般社団法人日本温泉気候物理医学会の論文