EFFECTS OF LOPERAMIDE ON THE MOTILITY OF THE ISOLATED INTESTINE IN GUINEA PIGS, RATS AND DOGS.
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Effects of Loperamide on the motility of the isolated intestine in guinea-pigs, puppies and rats were examined.<BR>The spontaneous contractions of the small intestine and colon in puppies were inhibited at relatively high concentration of the agent (10<SUP>-5</SUP> g/m1). The peristaltic reflex in the guinea-pig ileum was slightly inhibited at concentrations of 10<SUB>-8</SUB> to 10<SUB>-7</SUB> g/ml, and was completely abolished at 10<SUB>-6</SUB> g/ml. The agent (2×10<SUP>-7</SUP> g/ml) inhibited the longitudinal contraction of the guinea-pig ileum elicited by transmural electric stimulation. The agent (10<SUP>-5</SUP> g/ml) inhibite the acetylcholine-induced contraction of the colon and small intestine in puppies and induced the hyperpolarization of the membrane potential and the abolition of spike potentials of the intestinal muscle in rats.
- 日本平滑筋学会の論文
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