EFFECTS OF 1-(m-METHOXYPHENYL)-2-DIMETHYLAMINOMETHYL CYCLOHEXANOL (1) HYDROCHLORIDE (K-315) ON THE MOTILITY OF THE SMALL INTESTINE AND THE SPHINCTER OF ODDI
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Intravenous, intramuscular or subcutaneous administration of an effective analgetic, 1-(m-methoxyphenyl)-2-dimethylaminomethyl cyclohexanol (1) hydrochloride (K-315), increased the tone and motility of the small intestine and the sphincter of Oddi in the anesthetized dog and rabbit. The excitatory effect was not abolished after atropine.<BR>The small dose of the drug caused an increased contraction of the isolated small intestine in rabbits, while the large dose induced an inhibitory effect and also inhibited the increased contraction elicited by acetylcholine. After atropine or tetrodotoxin the excitatory response was not abolished. It is supposed that the small dose of K-315 stimulates directly the intestinal muscle.
- 日本平滑筋学会の論文
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