RELATIONSHIP BETWEEN ACTIVITIES OF THE SPHINCTER OF ODDI AND THE DUODENAL MUSCLE

概要

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To investigate the relationship between the activity of the sphincter of Oddi and that of the duodenal muscle, intracellular action potentials of them were recorded in the isolated preparation of the rabbit.<BR>The spontaneous rhythmic contraction of the sphincter of Oddi induced a retardation of the outflow of the perfusate through the common bile duct to the duodenal lumen, and when acetylcholine was administered there occurred tonic contraction which stopped the outflow of the perfusate.<BR>A burst of the spike potentials of the sphincter of Oddi was recorded synchronously to the longitudinal contraction of the duodenum (the pendular movements). The spike potentials in thelatter precede the former.<BR>Several hours after isolation of the preparation the sphincter of Oddi contracted independently of the longitudinal contraction of the entire duodenum. In such a case, a part of the duodenal muscle around the sphincter of Oddi discharged the spike potentials unsynchronously or synchronously to those in the latter.<BR>It is supposed from an anatomical structure and the facts described that there will be a functional connection between the sphincter of Oddi and the longitudinal muscle of the duodenum close to it.
日本平滑筋学会の論文