Development of the Liquid-type ECMO Oxygenator Made of Ethylene Vinyl Alcohol Copolymer Hollow Fibers

概要

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For the purpose of extracorporeal membrane oxygenation(ECMO), a liquid-type oxygenator was developed. It was made of ethylene vinyl alcohol copolymer(EVAL: Kuraray)hollow fibers which have been known to need few amount of anticoagulant in hemodialysis. The 1.2m<SUP>2</SUP> EVAL oxygenator was intracapillarily perfused with standard venous blood drained from an anesthetized dog and extracapillarily infused with 37°C saline solution oxygenated at normal atmospheric pressure with a polypropylene hollow fiber oxygenator(Capiox II 16, Terumo). Oxygen transfer was observed at 2.5ml/min across EVAL membrane between venous blood at the flow rate of 50ml/min and oxygen saturated saline at the flow rate of 1.0L/min while extracapillary pressure was kept 3cmHg higher than intracapillary one. Oxygen carrier solution shifted at the rate of 0.94ml/min/cm Hg across the EVAL membrane was ultrafiltrated with a dialyzer interposed in the blood circuit and recirculated to the solution circuit. However, oxygen transfer disappeared when the transmembrane pressure was reversed. This oxygenator system, functioning not only as an ECMO oxygenator without plasma leakage but also as a dialyzer when oxygen carrier solution was substituted with oxygenated dialysate. This liquid-type multifunctional oxygenator can be effective for the ECMO patient associated with multiple organ failure.
ライフサポート学会の論文