Asymmetric transformation of N-acetyl-DL-leucine.
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概要
- 論文の詳細を見る
The asymmetric transformation of <I>N</I>-acetyl-DL-leucine by a combination of preferential crystallization of a desired isomer and simultaneous racemization of the opposite isomer was studied. The reaction was analyzed in detail and a practical method for the asymmetric transformation was established. A supersaturated solution of <I>N</I>-Ac-DL-Leu in acetic acid containing catalytic amounts of acetic anhydride was seeded with the crystals of <I>N</I>-Ac-L-Leu and cooled at a rate of 10 °C/h from 100 °C to 40 °C. As a result, almost optically pure <I>N</I>-Ac-L-Leu was obtained in a yield of 70%, based on the original weight of <I>N</I>-Ac-DL-Leu.
- 公益社団法人 日本化学会の論文
著者
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Chibata Ichiro
Research Laboratories Tanabe Seiyaku Co. Ltd.
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Yamada Shigeki
Research Laboratories Tanabe Seiyaku Co. Ltd.
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Hongo Chikara
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.
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