Intramolecular stacking association of three dinucleoside monophosphates containing naturally-occurring 1-methyladenosine residue(s): m1ApA, Apm1A, and m1Apm1A.
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概要
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Three modified dinucleoside monophosphates containing naturally-occurring 1-methyladenosine residue, m<SUP>1</SUP>ApA, Apm<SUP>1</SUP>, and m<SUP>1</SUP>Apm<SUP>1</SUP>A, were prepared. Intramolecular stacking association properties of these dimers were studied quantitatively using two independent methods. Thermal denaturation and acid-base titration experiments reached to the same conclusion that both m<SUP>1</SUP>\overset+ApA and Apm<SUP>1</SUP>\overset+A were less stacked than ApA. Acidbase titration experiment also showed that the three modified dimers, in their neutral forms, were stacked to almost the same extent as ApA. These results indicate the N-1 methylation of an adenine base does not enhance stacking interaction of dimers, in sharp contrast to the N<SUP>6</SUP> methylation of the same base. UV hypochromicity and CD measurements were also made for the three dimers, and the results were found to be consistent with those of the stacking quotient determination.
著者
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INOUE Yasuo
Department of Applied Physics, Osaka University
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Takeuchi Yasuhiro
Department Of Applied Mathematics Faculty Of Engineering Shizuoka University
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Takeuchi Yasuhiro
Department of Biophysics and Biochemistry, Faculty of Science, The University of Tokyo
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Tazawa Ichiro
Department of Biophysics and Biochemistry, Faculty of Science, The University of Tokyo
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Inoue Yasuo
Department of Biophysics and Biochemistry, Faculty of Science, The University of Tokyo
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- Intramolecular stacking association of three dinucleoside monophosphates containing naturally-occurring 1-methyladenosine residue(s): m1ApA, Apm1A, and m1Apm1A.