Michael addition of methyl 2-(trimethylsilyl)propenoate with organomagnesiums or organolithiums leading to 1:1 and/or 2:1 adducts and subsequent Peterson olefination by condensation with carbonyl compounds.
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概要
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Michael addition of methyl 2-(trimethylsilyl)propenoate with organomagnesiums or organolithiums leads to 1:1 and/or 1:2 adduct anions which can be utilized in the subsequent step of Peterson olefination with carbonyl compounds. The 1:1/1:2 ratio depends upon the nature of donor molecules, the reaction conditions such as reaction temperature, polarity of solvent, and rate of addition of the acceptor molecule. Use of acceptors in excess results in the selective formation of 1:2 and/or 1:3 adducts.
- 公益社団法人 日本化学会の論文
著者
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Kanemasa Shuji
Institute Of Advanced Material Study Kyushu University
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Tanaka Junji
Institute Of Advanced Material Study Kyushu University
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Tsuge Otohiko
Institute of Advanced Material Study, and Department of Molecular Science and Technology, Interdisciplinary Graduate School of Engineering Sciences
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Ninomiya Yusuke
Institute of Advanced Material Study, and Department of Molecular Science and Technology, Interdisciplinary Graduate School of Engineering Sciences, Kyushu University
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