Michael Addition of Acyclic Lithium 1,3-Dien-2-olates with .ALPHA.,.BETA.-Unsaturated Esters, Ketones, and Diesters.
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概要
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The Michael addition of lithium 1,3-dien-2-olates with α,β-unsaturated carbonyl compounds is described. With α,β-unsaturated esters the reaction was reversible even at −78°C, while kinetically controlled with α,β-unsaturated ketones or alkylidenemalonates. At room temperature, the initially formed Michael adducts undergo subsequent intramolecular Michael addition to give substituted cyclohexanone derivatives in a highly stereoselective manner. Mostly <I>anti</I>-selectivity has been observed for the initial Michael addition, and the intramolecular cyclization was <I>cis</I>-selective.
- 公益社団法人 日本化学会の論文
著者
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Nomura Masafumi
Department Of Molecular Science And Technology Interdisciplinary Graduate School Of Engineering Scie
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Kanemasa Shuji
Institute Of Advanced Material Study Kyushu University
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Wada Eiji
Institute Of Advanced Material Study Kyushu University
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Nomura Masafumi
Department of Molecular Science and Technology, Interdisciplinary Graduate School of Engineering Sciences, Kyushu University
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Kumegawa Masahiro
Department of Molecular Science and Technology, Interdisciplinary Graduate School of Engineering Sciences, Kyushu University
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