The Synthesis of 2,3-Dimethoxy-5-methyl-<I>p</I>-benzoquinone
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概要
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2,3-Dimethoxy-5-methylbenzoquinone, the key intermediate of the synthesis of coenzyme Q, was synthesized <I>via</I> two new routes. The methylation of 5-nitrovanillin gave 5-nitroveratraldehyde, which was then catalytically reduced to afford 5-aminohomoveratrol. The oxidation of 5-aminohomoveratrol gave 2,3-dimethoxy-5-methylbenzoquinone. 2,3,4-Trimethoxyphenol was obtained by the decarboxylation of 3,4,5-trimethoxysalicylic acid. This was converted <I>via</I> Mannich reaction to 2,3,4-trimethoxy-6-methylphenol, which was then easily oxidized to 2,3-dimethoxy-5-methylbenzoquinone.
- 公益社団法人 日本化学会の論文
著者
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Sato Kikumasa
Department Of Applied Chemistry Faculty Of Engineering Yokohama National University
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Inoue Seiichi
Department Of Applied Chemistry Faculty Of Engineering Yokohama National University
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Sato Haruhito
Department of Applied Chemistry, Faculty of Engineering, Yokohama National University
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