A-substituted 5.BETA.-steroids. VIII. Synthesis and bromination of 3-alkyl-5.BETA.-cholestan-2-one.
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概要
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3α-Alkyl-5β-cholestan-2-one (R=CH<SUB>3</SUB>, C<SUB>2</SUB>H<SUB>5</SUB>, and CH<SUB>3</SUB>CH<SUB>2</SUB>CH<SUB>2</SUB>) was prepared by the direct alkylation of 5β-cholestan-2-one with alkyl iodide and potassium <I>t</I>-butoxide in a reflux of <I>t</I>-butyl alcohol-benzene. The 3α-benzyl ketone was prepared from 5β-cholestan-2-one by aldol condensation with benzaldehyde in the presence of potassium hydroxide, followed by hydrogenation of the condensation product. The bromination of these 3α-alkyl ketones gave 3β-bromo-3α-alkyl-5β-cholestan-2-ones.
- 公益社団法人 日本化学会の論文
著者
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Horiuchi C.
Department Of Chemistry Rikkyo (st. Paul's) University
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SATOH J.
Department of Pediatrics, Department of Pathology, Tokyo Metropolitan Bokuto Hospital and Department
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HORIUCHI C.
Department of Chemistry, Rikkyo (St. Paul's) University
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Hagitani Akira
Department of Chemistry, St. Paul's (Rikkyo) University
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Hagitani Akira
Department of Chemistry, College of Science, Rikkyo (St. Paul's) University
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Satoh J.
Department of Chemistry, Rikkyo (St. Paul's) University
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