Novel regioselective iodination of estradiol 17.BETA.-acetate.
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概要
- 論文の詳細を見る
Direct iodination of estradiol 17β-acetate (<B>3</B>) using iodine–copper(II) acetate in acetic acid afforded the 2-iodo derivative regioselectively in high yield. The iodination of <B>3</B> using several methods was discussed. On the other hand, the reaction of <B>3</B> with iodine–copper(II) bromide gave the 4-bromo derivative (<B>7</B>), not the 2-iodo compound. The reaction of 3-methoxy-17β-acetoxy-1,3,5(10)-estratriene (<B>4</B>) with iodine–copper(II) chloride–iron(III) chloride in acetic acid gave the 2- (<B>10</B>) and 4-iodo (<B>11</B>) derivative.
- 公益社団法人 日本化学会の論文
著者
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Horiuchi C.
Department Of Chemistry Rikkyo (st. Paul's) University
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SATOH J.
Department of Pediatrics, Department of Pathology, Tokyo Metropolitan Bokuto Hospital and Department
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Haga Akinori
Department of Chemistry, Rikkyo (St. Paul's) University
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