正常者, 甲状腺機能亢進症, 原発性甲状腺機能低下症及び糖尿病におけるTolbutamide投与による血中Gastrinの動態
スポンサーリンク
概要
- 論文の詳細を見る
The basal values and changes of gastrin in serum produced by tolbutamide (Tol.) induced hypoglycemia were studied in the present experiment where 30 normal controls, 23 patients with hyperthyroidism, 9 patients with primary hypothyroidism and 7 diabetics were employed. After overnight fasting, 1.0 or 0.5 g of Tol was administered iv to each subject immediately after the basal blood sample was taken. Venous blood samples were again withdrawn at 5, 15, 30, 45, 60, 90,120,150 and 180 min after the start of the injections. An acute and marked increase of immunoreactive insulin within 15 min was followed by a clear decrease of blood sugar (BS), the so-called Tol-induced hypoglycemia, after the Tol injection. In the normal control, the Tol injection resulted in hypoglycemia, (46.0±2.0 mg/100 ml) at 30 min. The mean basal gastrin level was 61±3 pg/ml. The gastrin level in serum began to increase at 30 min and reached a maximum (95±10 pg/ml) at 45 min after the treatment. This peak value of gastrin was significantly higher (P<0.001) than the basal one. The basal value of gastrin in all of the hyperthyroid patients was 90±6 pg/ml, and this value was significantly higher (P<0.05) than in the normal controls. In these subjects, 0.5 g of Tol was administered to obtain almost the same hypoglycemic effect as that in controls injected with 1.0 g of the agent. In 7 out of 23 patients, marked basal hypergastrinemia (140±10 pg/ml) was found. These patients didn't show the consistent response of serum gastrin to Tol injection despite the adequately induced hypoglycemia (47.1±6.4 mg/100 ml). In the other 16 patients, the initial values of serum gastrin were less than 100 pg/ml, and in 11 out of these subjects, Tol stimulated clearly to increase the gastrin level in serum at 60 min up to approximately twice as much as the basal one (from 73±5 to 145 ± 17 pg/ml). In contrast, no response of serum gastrin to Tol was observed in the rest of the 16 patients who showed relatively milder hypoglycemia (nadir of BS 56.0±4.6 mg/100 ml) than the former group (47.5± 4.6 mg/100 ml). In primary hypothyroidism, they had relatively low initial levels of serum gastrin (49±11 pg/ml). This value was not significant compared with normal controls, but significantly (P<0.02) lower than that of hyperthyroidism. Moreover, no response of serum gastrin to 1 g Tol injection was observed, although the induced hypoglycemia ensued adequately (43.0±2.6 mg/100 ml). This hyporesponsiveness of serum gastrin in hypothyroidism was significantly lower compared with normal controls and hyperthyroidism (P<0.05 and P<0.05, respectively). Also in the diabetics who had normal gastrin levels in basal state (59±7 pg/ml), no response of serum gastrin to Tol (1.0 g) was noticed. This would be due to slow decrease of BS.<BR>From these results, we confirmed that the Tol-induced hypoglycemia clearly stimulates an increase in serum gastrin levels and that in response to Tol serum thyroid hormone promotes basal gastrin release.
- 日本内分泌学会の論文
著者
関連論文
- Sulpirideの膵内分泌系に及ぼす影響
- アルドステロン分泌におけるドバミン作動性調節
- 甲状腺機能異常者における血清Myoglobin, Creatine PhosphokinaseおよびLactic Dehydrogenasel貝掟の診断的意義
- 正常者, 甲状腺機能亢進症, 原発性甲状腺機能低下症及び糖尿病におけるTolbutamide投与による血中Gastrinの動態
- 血中Prolactin濃度と甲状腺ホルモン濃度との相関関係について
- 糖尿病の脳下垂体成長ホルモン分泌異常に関する臨床的研究
- 成長ホルモンに関する臨床的研究
- 血清蛋白の甲状腺ホルモン結合能に関する研究 特に急性肝炎について
- タイトル無し
- タイトル無し
- 非甲状腺疾患患者の甲状腺機能:疾患に特異的な甲状腺ホルモンの変化および血中遊離ホルモンと血中TSHとの相関
- タイトル無し
- タイトル無し