非甲状腺疾患患者の甲状腺機能:疾患に特異的な甲状腺ホルモンの変化および血中遊離ホルモンと血中TSHとの相関
スポンサーリンク
概要
- 論文の詳細を見る
In order to assess the thyroid function of patients with nonthyroidal illness, 292 patients with nonthyroidal illness were employed in the present study. These patients were then subdivided into 6 groups according to their original illness. The groups consisted of patients with malignant illnesses (19 males and 10 females; mean age of 59.7 yr.), with chronic hepatitis (14 males and 8 females; mean age of 55.2 yr.), with liver cirrhosis (5 males and 6 females, mean age of 60.4 yr.), with uremia who had been receiving constant hemodialysis 2-3 times per week (52 males and 38 females; mean age of 48.1 yr.), with diabetes mellitus (50 males and 43 females; mean age of 52.3 yr.) and with cerebrovascular accident (21 males and 26 females; mean age of 74.9 yr.). In addition, 34 healthy persons (15 males and 19 females; mean age of 41.6 yr.) were also employed as controls. Because the differences between mean ages in these groups were significant, the relationship between age and thyroid function was examined. Significant positive correlations between age and total thyroxine (TT4) (r=0.19; p<0.01), and reverse triiodothyronine (rT3) (r=0.175; p<0.01) were found. A negative correlation was also found between age and total triiodothyronine (TT3) (r=-0.231; p<0.01). The serum levels of rT3 were elevated in patients with neoplasma and liver cirrhosis but significantly low in patients with uremia. These characteristic findings were correlated with the severity of each original disease such as % motarity, serum levels of cholinesterase, blood urea nitrogens and the blood sugar control in the diabetics.<BR>In these circumstances, multiple correlation analyses were performed in order to assess whether there might exist a negative feedback mechanism between thyrotropin and FT4/FT3. The highest partial correlation coefficient was obtained between thyrotropin and FT4. It might, therefore, be concluded that in patients with a nonthyroidal illness, decreased levels of serum thyroid hormones indicate not only the severity of the illness but also the supposed presence of a hypothyroid state.
- 一般社団法人 日本内分泌学会の論文
著者
関連論文
- Sulpirideの膵内分泌系に及ぼす影響
- アルドステロン分泌におけるドバミン作動性調節
- 甲状腺機能異常者における血清Myoglobin, Creatine PhosphokinaseおよびLactic Dehydrogenasel貝掟の診断的意義
- 正常者, 甲状腺機能亢進症, 原発性甲状腺機能低下症及び糖尿病におけるTolbutamide投与による血中Gastrinの動態
- 血中Prolactin濃度と甲状腺ホルモン濃度との相関関係について
- 糖尿病の脳下垂体成長ホルモン分泌異常に関する臨床的研究
- 成長ホルモンに関する臨床的研究
- 血清蛋白の甲状腺ホルモン結合能に関する研究 特に急性肝炎について
- タイトル無し
- タイトル無し
- 非甲状腺疾患患者の甲状腺機能:疾患に特異的な甲状腺ホルモンの変化および血中遊離ホルモンと血中TSHとの相関
- タイトル無し
- タイトル無し